{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327968/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327968"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression profiling of GLP1R-IL17A axis in obesity driven PTPN11-mutant leukemia","description":"Obesity-associated metabolic inflammation contributes to the progression of PTPN11-mutant myeloid leukemia through activation of the IL-17A–mediated inflammatory axis and suppression of GLP-1R signaling. In this study, mRNA-seq was performed on hematopoietic and immune cell populations from a murine transplantation model of Shp2E76K/+ leukemia under obese conditions, with or without treatment using an anti-IL-17A antibody and a GLP-1R agonist. Transcriptomic analysis reveals that obesity promotes leukemogenesis by enhancing myeloid expansion, lipid metabolic reprogramming, and immunosuppressive remodeling characterized by M2-like tumor-associated macrophage accumulation, T cell exhaustion, and impaired antigen presentation. Therapeutic targeting of the GLP-1R–IL-17A axis restores immune function, including Ciita-dependent antigen presentation and IFNγ signaling, and reduces leukemic burden. These data provide insight into the molecular mechanisms linking obesity-driven inflammation to leukemia progression and identify potential therapeutic targets.","dates":{"publication":"2026/04/15"},"accession":"GSE327968","cross_references":{"GSM":["GSM9669523","GSM9669501","GSM9669522","GSM9669525","GSM9669503","GSM9669524","GSM9669502","GSM9669521","GSM9669520","GSM9669509","GSM9669508","GSM9669527","GSM9669505","GSM9669504","GSM9669526","GSM9669507","GSM9669529","GSM9669528","GSM9669506","GSM9669512","GSM9669511","GSM9669514","GSM9669513","GSM9669530","GSM9669510","GSM9669519","GSM9669516","GSM9669515","GSM9669518","GSM9669517"],"GPL":["34290"],"GSE":["327968"],"taxon":["Mus musculus"]}}