GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327968/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327968GEOGSEfalseGene expression profiling of GLP1R-IL17A axis in obesity driven PTPN11-mutant leukemiaObesity-associated metabolic inflammation contributes to the progression of PTPN11-mutant myeloid leukemia through activation of the IL-17A–mediated inflammatory axis and suppression of GLP-1R signaling. In this study, mRNA-seq was performed on hematopoietic and immune cell populations from a murine transplantation model of Shp2E76K/+ leukemia under obese conditions, with or without treatment using an anti-IL-17A antibody and a GLP-1R agonist. Transcriptomic analysis reveals that obesity promotes leukemogenesis by enhancing myeloid expansion, lipid metabolic reprogramming, and immunosuppressive remodeling characterized by M2-like tumor-associated macrophage accumulation, T cell exhaustion, and impaired antigen presentation. Therapeutic targeting of the GLP-1R–IL-17A axis restores immune function, including Ciita-dependent antigen presentation and IFNγ signaling, and reduces leukemic burden. These data provide insight into the molecular mechanisms linking obesity-driven inflammation to leukemia progression and identify potential therapeutic targets.2026/04/15GSE327968GSM9669523GSM9669501GSM9669522GSM9669525GSM9669503GSM9669524GSM9669502GSM9669521GSM9669520GSM9669509GSM9669508GSM9669527GSM9669505GSM9669504GSM9669526GSM9669507GSM9669529GSM9669528GSM9669506GSM9669512GSM9669511GSM9669514GSM9669513GSM9669530GSM9669510GSM9669519GSM9669516GSM9669515GSM9669518GSM966951734290327968Mus musculus