GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327983/primaryOK200OtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327983GEOGSEfalseSpatial proteogenomics reveals S100-RAGE axis as a druggable mediator of trastuzumab deruxtecan resistance in metastatic breast cancer.Trastuzumab deruxtecan (T-DXd) has substantially improved outcomes for HER2-positive metastatic breast cancer, yet up to 30 percent of patients with high HER2 expression exhibit de novo resistance. Mechanisms underlying this intrinsic resistance, particularly across different metastatic sites, remain poorly understood.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 sapiens[42467226]