{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328096/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328096"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy","description":"Here we report the single-cell RNA sequencing (scRNA-seq) analysis of retinas from WT and Epac1-knockout mice under Oxygen-Induced Retinopathy (OIR) and Room Air (RA) conditions. The OIR model was induced by exposing pups to 70% oxygen from postnatal day 7 (P7) to P12. This study aims to delineate the cellular heterogeneity and investigate the neuroprotective mechanisms associated with Epac1 deletion, with a specific focus on Müller glial pathological activation and retinal neurodegeneration. Retinal tissues were collected at postnatal day 17 (P17) to establish a comprehensive transcriptomic profile of the ischemia-induced retinopathy model.","dates":{"publication":"2026/04/15"},"accession":"GSE328096","cross_references":{"GSM":["GSM9672360","GSM9672357","GSM9672358","GSM9672359"],"GPL":["19057"],"GSE":["328096"],"taxon":["Mus musculus"],"PMID":["[40976555]"]}}