{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328129/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328129"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury","description":"Macrophage-mediated inflammation is among the most important characteristics of hypertension-induced CKD, but the molecular events that drive these processes are poorly understood. Here, we conducted single cell RNA sequencing (scRNA-seq) of deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mouse model to characterize the change of cell signaling in macrophages of mouse kidneys. Our scRNA-seq data confirmed that the proportion of macrophages was the most significantly altered cell type among all clusters in response to DOCA-salt treatment. In addition, P2X7 was specifically enriched in macrophages, and NLRP3 signaling was significantly enriched in macrophage DEGs. Our scRNA-seq data showed that P2X7/NLRP3-related pyroptosis pathway was activated in macrophages of DOCA-salt treated mice.","dates":{"publication":"2026/08/12"},"accession":"GSE328129","cross_references":{"GSM":["GSM9672825","GSM9672826","GSM9672827","GSM9672828","GSM9672829","GSM9672830"],"GPL":["24247"],"GSE":["328129"],"taxon":["Mus musculus"],"PMID":["[42552307]"]}}