{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328184/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328184"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"CHCHD10 alleviates Alzheimer’s Disease Pathogenesis by Modulating Epigenetic Landscape in Directly Reprogrammed Neurons","description":"Alzheimer’s disease (AD) is associated with widespread epigenetic alterations, including changes in DNA methylation. CHCHD10, a mitochondrial intermembrane space protein, has been implicated in mitochondrial function and neurodegeneration, but its role in epigenetic regulation remains unclear. In this study, we performed genome-wide DNA methylation profiling in fibroblast-derived induced neurons from cognitively normal controls (NC) and AD patients, with and without CHCHD10 overexpression. We identified disease-associated differentially methylated regions (DMRs) and evaluated the extent to which CHCHD10 restoration modulates these epigenetic signatures. This dataset provides a resource for understanding mitochondrial-epigenetic interactions in AD.","dates":{"publication":"2026/06/29"},"accession":"GSE328184","cross_references":{"GSM":["GSM9674590","GSM9674592","GSM9674591","GSM9674594","GSM9674593","GSM9674596","GSM9674595","GSM9674598","GSM9674597","GSM9674589","GSM9674588","GSM9674599"],"GPL":["24676"],"GSE":["328184"],"taxon":["Homo sapiens"]}}