GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328184/primary200OKMethylation profilingHomo sapiensMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328184GEOGSEfalseCHCHD10 alleviates Alzheimer’s Disease Pathogenesis by Modulating Epigenetic Landscape in Directly Reprogrammed NeuronsAlzheimer’s disease (AD) is associated with widespread epigenetic alterations, including changes in DNA methylation. CHCHD10, a mitochondrial intermembrane space protein, has been implicated in mitochondrial function and neurodegeneration, but its role in epigenetic regulation remains unclear. In this study, we performed genome-wide DNA methylation profiling in fibroblast-derived induced neurons from cognitively normal controls (NC) and AD patients, with and without CHCHD10 overexpression. We identified disease-associated differentially methylated regions (DMRs) and evaluated the extent to which CHCHD10 restoration modulates these epigenetic signatures. This dataset provides a resource for understanding mitochondrial-epigenetic interactions in AD.2026/06/29GSE328184GSM9674590GSM9674592GSM9674591GSM9674594GSM9674593GSM9674596GSM9674595GSM9674598GSM9674597GSM9674589GSM9674588GSM967459924676328184Homo sapiens