{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328230/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328230"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ATAC-seq profiling reveals that KLF2 regulates chromatin accessibility programs in HCC","description":"Krüppel-like factor 2 (KLF2) is a tumor-suppressive transcription factor implicated in the regulation of epithelial-mesenchymal plasticity in hepatocellular carcinoma (HCC). In this study, we performed ATAC-seq in HCCLM3 human HCC cells with or without KLF2 overexpression to characterize KLF2-associated changes in chromatin accessibility. Comparative analysis was used to identify differentially accessible chromatin regions and to investigate how KLF2 affects the transcriptional programs associated with Hippo/YAP signaling and EMT/pEMT-related cell plasticity.","dates":{"publication":"2026/04/21"},"accession":"GSE328230","cross_references":{"GSM":["GSM9675393","GSM9675392","GSM9675394","GSM9675391"],"GPL":["24676"],"GSE":["328230"],"taxon":["Homo sapiens"]}}