{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328335/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328335"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic and epigenomic analysis of WSTF knockdown in colorectal cancer cells [ChIP-Seq]","description":"This study investigates the role of Williams syndrome transcription factor (WSTF/BAZ1B) in colorectal cancer (CRC) progression through multi-omics approaches. WSTF was knocked down in SW620 colorectal cancer cells using siRNA to assess its impact on gene expression and metabolism. Additionally, WSTF overexpression was performed followed by ChIP-seq to identify genome-wide binding sites and direct transcriptional targets. The study aims to elucidate WSTF-mediated regulatory mechanisms and identify potential downstream effectors including GLYCTK in CRC.","dates":{"publication":"2026/04/22"},"accession":"GSE328335","cross_references":{"GSM":["GSM9679486","GSM9679485"],"GPL":["24676"],"GSE":["328335"],"taxon":["Homo sapiens"]}}