{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328360/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328360"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Laminaria japonica Polysaccharide Mitigates Acute Neuroinflammation in Cerebral Ischemia-Reperfusion Injury","description":"Cerebral ischemia-reperfusion (I/R) injury triggers acute neuroinflammation, which exacerbates neuronal damage and functional deficits. Laminaria japonica polysaccharide (LJP) has been reported to exert anti-inflammatory and neuroprotective effects, but its molecular mechanisms in I/R injury remain unclear. In this study, we performed transcriptome sequencing on ischemic brain tissues from Sham, Vehicle, and LJP-treated mice to elucidate the molecular mechanisms underlying LJP’s anti-inflammatory actions. Our results show that LJP treatment significantly modulated the expression of key genes involved in inflammatory responses, particularly through the regulation of Csf3-mediated pathways. These findings provide novel insights into the therapeutic potential of LJP for ischemic stroke and identify potential targets for future interventions.","dates":{"publication":"2026/04/22"},"accession":"GSE328360","cross_references":{"GSM":["GSM9679929","GSM9679931","GSM9679930","GSM9679940","GSM9679935","GSM9679934","GSM9679933","GSM9679932","GSM9679939","GSM9679938","GSM9679937","GSM9679936"],"GPL":["24247"],"GSE":["328360"],"taxon":["Mus musculus"]}}