GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328360/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328360GEOGSEfalseLaminaria japonica Polysaccharide Mitigates Acute Neuroinflammation in Cerebral Ischemia-Reperfusion InjuryCerebral ischemia-reperfusion (I/R) injury triggers acute neuroinflammation, which exacerbates neuronal damage and functional deficits. Laminaria japonica polysaccharide (LJP) has been reported to exert anti-inflammatory and neuroprotective effects, but its molecular mechanisms in I/R injury remain unclear. In this study, we performed transcriptome sequencing on ischemic brain tissues from Sham, Vehicle, and LJP-treated mice to elucidate the molecular mechanisms underlying LJP’s anti-inflammatory actions. Our results show that LJP treatment significantly modulated the expression of key genes involved in inflammatory responses, particularly through the regulation of Csf3-mediated pathways. These findings provide novel insights into the therapeutic potential of LJP for ischemic stroke and identify potential targets for future interventions.2026/04/22GSE328360GSM9679929GSM9679931GSM9679930GSM9679940GSM9679935GSM9679934GSM9679933GSM9679932GSM9679939GSM9679938GSM9679937GSM967993624247328360Mus musculus