GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328454/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328454GEOGSEfalseGene expression profiling of A498 clear cell renal cell carcinoma cells following HIF1A and HIF2A knockdownThis dataset investigates hypoxia-associated transcriptional regulation in clear cell renal cell carcinoma. Following the identification of hypoxia-related gene programs in malignant cells, siRNA-mediated knockdown of HIF1A, HIF2A, or both was performed in A498 cells. RNA sequencing and differential gene expression analysis were used to identify gene signatures specifically regulated by HIF1A or HIF2A.2026/07/20GSE328454GSM9683865GSM9683866GSM9683863GSM9683864GSM9683861GSM9683862GSM9683870GSM9683860GSM9683869GSM9683859GSM9683867GSM968386824676328454Homo sapiens