{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328459/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328459"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlie Shh-Medulloblastoma Formation","description":"We identify a rare Nestin-expressing granule cell precursor (GCP) subpopulation in the normal early postnatal cerebellum and show that it is spatially restricted, molecularly distinct and highly competent to form SHH-MB. Single cell RNA sequencing revealed Nestin-expressing GCPs have a transcriptome indicating reduced neuronal differentiation and enrichment for stem cell genes compared to bulk GCPs and more closely align with SHH MB cells.","dates":{"publication":"2026/08/11"},"accession":"GSE328459","cross_references":{"GSM":["GSM9683937","GSM9683938","GSM9683935","GSM9683936","GSM9683934"],"GPL":["24247"],"GSE":["328459"],"taxon":["Mus musculus"],"PMID":["[42244536]"]}}