GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328459/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328459GEOGSEfalseA Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlie Shh-Medulloblastoma FormationWe identify a rare Nestin-expressing granule cell precursor (GCP) subpopulation in the normal early postnatal cerebellum and show that it is spatially restricted, molecularly distinct and highly competent to form SHH-MB. Single cell RNA sequencing revealed Nestin-expressing GCPs have a transcriptome indicating reduced neuronal differentiation and enrichment for stem cell genes compared to bulk GCPs and more closely align with SHH MB cells.2026/08/11GSE328459GSM9683937GSM9683938GSM9683935GSM9683936GSM968393424247328459Mus musculus[42244536]