GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328561/primaryOK200TranscriptomicsHomo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328561GEOGSEfalseLongitudinal single-cell multi-omic profiling of PBMC from the TARA cohort: infants with perinatal HIV during antiretroviral therapyThis study investigated longitudinal changes in immune cell composition, transcriptional states, and lymphocyte receptor repertoires in infants with perinatally acquired HIV during antiretroviral therapy (ART). Peripheral blood mononuclear cells (PBMC) were collected at multiple timepoints from infants in the TARA cohort, spanning pre-ART entry through follow-up visits at 12, 24, and up to 44 months of age. Single-cell CITE-seq (5' gene expression and surface protein) and V(D)J sequencing (BCR/TCR) were performed to profile immune dynamics over time. Infants were stratified by virological outcome on ART—virally suppressed versus viremic/unsuppressed—to identify cell types, gene expression programs, and clonal repertoire features associated with durable viral suppression or persistent viremia during early life ART.2026/09/30GSE328561GSM9685307GSM9685306GSM9685305GSM9685349GSM9685348GSM9685304GSM9685347GSM9685303GSM9685302GSM9685346GSM9685345GSM9685301GSM9685300GSM9685344GSM9685343GSM9685342GSM9685341GSM9685340GSM9685318GSM9685317GSM9685316GSM9685315GSM9685314GSM9685313GSM9685312GSM9685311GSM9685310GSM9685351GSM9685350GSM9685309GSM9685308GSM9685329GSM9685328GSM9685327GSM9685326GSM9685325GSM9685324GSM9685323GSM9685322GSM9685321GSM9685320GSM9685319GSM9685339GSM9685338GSM9685337GSM9685336GSM9685335GSM9685334GSM9685333GSM9685332GSM9685331GSM968533034284328561Homo sapiens