GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328671/suppl/filelist.txtftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328671/suppl/GSE328671_RAW.tarftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328671/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328671GEOGSEfalse4T1 ATAC-seqMammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.2026/06/16GSE328671GSM9687030GSM9687031GSM9687032GSM9687033GSM9687034GSM9687035GSM9687036GSM9687025GSM9687026GSM9687027GSM9687028GSM968702934475328671Mus musculus