GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328672/suppl/filelist.txtftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328672/suppl/GSE328672_RAW.tarftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328672/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328672GEOGSEfalse4T1 Cut&RunMammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.2026/06/16GSE328672GSM9687050GSM9687051GSM9687040GSM9687041GSM9687052GSM9687042GSM9687043GSM9687044GSM9687045GSM9687046GSM9687047GSM9687048GSM9687037GSM9687038GSM9687049GSM968703934475328672Mus musculus