{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328693/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328693"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of FACS-sorted pre-metastatic lung endothelial cells reveal transcriptional programs regulated by cisplatin and FAK in the pre-metastatic lung","description":"This study investigates the mechanisms underlying DNA-damage driven vascular endothelial-cell senescence regulated by EC-FAK and its role in lung cancer metastasis. RNA-seq analysis has been performed FACS-sorted pre-metastatic lung endothelial cells to identify FAK-regulated transcriptomic changes due to DNA- damaging therapy in tumour burdened and non-tumour burdened mice (comparisons between Cre-negative ECFAK WT mice with Cre-positive ECFAK KO mice in Cisplatin treated samples.","dates":{"publication":"2026/09/09"},"accession":"GSE328693","cross_references":{"GSM":["GSM9687470","GSM9687450","GSM9687430","GSM9687452","GSM9687454","GSM9687432","GSM9687456","GSM9687434","GSM9687457","GSM9687436","GSM9687459","GSM9687438","GSM9687439","GSM9687461","GSM9687463","GSM9687441","GSM9687465","GSM9687443","GSM9687466","GSM9687445","GSM9687423","GSM9687468","GSM9687447","GSM9687425","GSM9687448","GSM9687427","GSM9687429"],"GPL":["24247"],"GSE":["328693"],"taxon":["Mus musculus"],"PMID":["[42687863]"]}}