GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328697/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328697GEOGSEfalseImproving Ovarian Cancer Immunotherapy through Discoidin Domain Receptor 2 BlockadeSerous ovarian carcinoma (SOC) is among the most aggressive gynaecological cancers, characterised by high relapse rates and poor prognosis due to chemoresistance. Disease progression is supported by a tumour microenvironment (TME) enriched in dense collagen type I (Col1) fibres, promoting tumour growth and invasion while restricting T-cell infiltration. Discoidin domain receptor 2 (DDR2), a collagen-binding receptor tyrosine kinase, has emerged as a driver of tumour progression and immune exclusion, although its role in SOC immunotherapy resistance remains unclear. Here we show that the inhibition of DDR2/Col1 interaction with WRG-28 in OVCA433 and OVCAR3 cells remodels the collagen matrix, favouring the recruitment, activation and cytotoxic activity of tumour-specific T cells.2026/08/24GSE328697GSM9687650GSM9687651GSM9687640GSM9687641GSM9687652GSM9687653GSM9687642GSM9687654GSM9687643GSM9687655GSM9687644GSM9687645GSM9687656GSM9687635GSM9687657GSM9687646GSM9687658GSM9687647GSM9687636GSM9687648GSM9687637GSM9687638GSM9687649GSM968763928038328697Homo sapiens