GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328705/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328705GEOGSEfalseDivergent Cytotoxic and Inflammatory Functions of Intratumoral Vd2+ gdT Cells in Renal Cell CarcinomaWe characterized Vd2+ gdT cell subsets in paired peripheral blood and tumor samples from three treatment-naive clear cell renal cell carcinoma (ccRCC) patients using flow cytometry and single-cell RNA sequencing. Two major subsets distinguished by CD16 expression exhibited divergent cytotoxic and inflammatory effector programs within the tumor microenvironment. Single-cell RNA sequencing identified four transcriptional clusters with a TOX+ progenitor-like cluster giving rise to divergent effector states.2026/08/06GSE328705GSM9687954GSM9687955GSM968795624676328705Homo sapiens[42539629]