{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328742/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328742"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Smad4/SKI/SKIL-mediated chromatin accessibility changes during the CD8 T cell response","description":"Transforming growth factor-β (TGF-β) is an immunosuppressive cytokine that regulates both innate and adaptive immune responses. Earlier studies have shown that TGF-β plays a role in promoting T cell exhaustion during the later stages of chronic viral infection. In this dataset we examined the global chromatin accessibility changes in CD8 T cells that are dependent on SMAD4. Our findings documenting the striking requirement for Smad4-SKI-SKIL mediated restraint of TGF-β-associated program during the effector phase of the CD8 T cell response have implications for developing immunotherapeutic approaches against chronic viral infections and cancer.","dates":{"publication":"2026/09/03"},"accession":"GSE328742","cross_references":{"GSM":["GSM9688450","GSM9688452","GSM9688451","GSM9688454","GSM9688453","GSM9688445","GSM9688456","GSM9688455","GSM9688444","GSM9688458","GSM9688447","GSM9688457","GSM9688446","GSM9688449","GSM9688448","GSM9688459"],"GPL":["24247"],"GSE":["328742"],"taxon":["Mus musculus"]}}