GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328742/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328742GEOGSEfalseSmad4/SKI/SKIL-mediated chromatin accessibility changes during the CD8 T cell responseTransforming growth factor-β (TGF-β) is an immunosuppressive cytokine that regulates both innate and adaptive immune responses. Earlier studies have shown that TGF-β plays a role in promoting T cell exhaustion during the later stages of chronic viral infection. In this dataset we examined the global chromatin accessibility changes in CD8 T cells that are dependent on SMAD4. Our findings documenting the striking requirement for Smad4-SKI-SKIL mediated restraint of TGF-β-associated program during the effector phase of the CD8 T cell response have implications for developing immunotherapeutic approaches against chronic viral infections and cancer.2026/09/03GSE328742GSM9688450GSM9688452GSM9688451GSM9688454GSM9688453GSM9688445GSM9688456GSM9688455GSM9688444GSM9688458GSM9688447GSM9688457GSM9688446GSM9688449GSM9688448GSM968845924247328742Mus musculus