GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328772/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328772GEOGSEfalseJagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph NodesTo investigate the role of Jag1⁺ Tregs in regulating the activity of tumours and corresponding tdLNs in the B16-F10 tumour model, we performed bulk RNA sequencing on tumours and tdLNs of wild-type mice and mice with conditional deletion of Jag1 in Tregs. Transcriptomic analysis revealed no significant changes in gene expression in tumours, whereas tdLNs exhibited downregulation of lymphatic endothelial cell (LEC)-related markers and genes related to cell junction organization in mice with Treg-specific Jag1 ablation.2026/05/18GSE328772GSM9689521GSM9689520GSM9689523GSM9689522GSM9689525GSM9689524GSM9689527GSM9689516GSM9689526GSM9689515GSM9689518GSM9689517GSM968951924247328772Mus musculus