{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328808/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328808"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Alpha Protein Kinase 3 Gene Therapy Restores Heart Function in Mouse and Human Models of Cardiomyopathy","description":"Here, we generated single-nucleus RNA sequencing (snRNA-seq) data from hiPSC-derived cardiac monolayers carrying TTN heterozygous (TTNhet) and TTN homozygous (TTNhom) truncating variant, alongside their PB10.5 wild-type (WT) isogenic control. Differential gene expression provided insight into the impact of TTN variants on sarcomeric gene expression.","dates":{"publication":"2026/06/18"},"accession":"GSE328808","cross_references":{"GSM":["GSM9690060"],"GPL":["24676"],"GSE":["328808"],"taxon":["Homo sapiens"]}}