GEOMethylation profilingHomo sapiensMethylation profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328810GEOGSEfalseEpisignatures associated with 8-week combined physical exercise in women with obesityAims: Obesity is influenced by epigenetic mechanisms; however, little is known about DNA methylation markers associated with exercise-induced health-promotion interventions. This aims to explore the episignatures of an 8-week combined physical exercise training protocol on DNA methylation patterns in women with obesity. Patients and Methods: Thirteen women with obesity (BMI: 33 ± 2 kg/m²; age: 34 ± 5 years) underwent assessments of body composition, waist circumference, physical performance (VO₂max), and peripheral blood collection before and after an 8-week combined physical training intervention (3 sessions/week, 55 minutes/session, 70-90% maximum heart rate). DNA methylation was analyzed using the Illumina EPIC BeadChip. Results: The intervention improved clinical outcomes, including reduced waist circumference and increased VO₂max (p < 0.05). Epigenome-wide analysis identified 15 differentially methylated regions, highlighting hypomethylation in SLFN11 and PM20D1 hypermethylation in GATA5. These genes are involved in pathways related to immune response, tumor suppression, thermogenesis, metabolic regulation, adiposity, glucose homeostasis, and transcriptional control. Conclusion: Combined physical training induced clinical improvements and DNA methylation changes in women with obesity, suggesting that exercise may alter the episignatures related to obesity.2026/04/23GSE328810GSM9690088GSM9690066GSM9690087GSM9690065GSM9690064GSM9690086GSM9690085GSM9690063GSM9690069GSM9690068GSM9690067GSM9690080GSM9690084GSM9690083GSM9690082GSM9690081GSM9690077GSM9690076GSM9690075GSM9690074GSM9690079GSM9690078GSM9690073GSM9690072GSM9690071GSM969007021145328810Homo sapiens