{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328820/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328820"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk RNA-seq of PBMCs collected before and 4 weeks after secukinumab treatment from plaque psoriasis patients with distinct 52-week clinical response trajectories","description":"This study profiles peripheral blood mononuclear cell (PBMC) transcriptomes from patients with plaque psoriasis treated with secukinumab. Samples were collected at baseline and at week 4 after treatment initiation from 27 patients representing two distinct 52-week PASI response trajectories (optimal and suboptimal). The dataset was generated to investigate baseline molecular differences between trajectory groups and early transcriptomic changes associated with subsequent long-term clinical response.","dates":{"publication":"2026/08/19"},"accession":"GSE328820","cross_references":{"GSM":["GSM9690259","GSM9690258","GSM9690264","GSM9690263","GSM9690262","GSM9690261","GSM9690268","GSM9690267","GSM9690266","GSM9690265","GSM9690260","GSM9690249","GSM9690248","GSM9690247","GSM9690253","GSM9690252","GSM9690251","GSM9690250","GSM9690257","GSM9690256","GSM9690255","GSM9690254","GSM9690290","GSM9690239","GSM9690238","GSM9690237","GSM9690286","GSM9690242","GSM9690285","GSM9690241","GSM9690240","GSM9690284","GSM9690283","GSM9690246","GSM9690245","GSM9690289","GSM9690288","GSM9690244","GSM9690243","GSM9690287","GSM9690282","GSM9690281","GSM9690280","GSM9690269","GSM9690275","GSM9690274","GSM9690273","GSM9690272","GSM9690279","GSM9690278","GSM9690277","GSM9690276","GSM9690271","GSM9690270"],"GPL":["20795"],"GSE":["328820"],"taxon":["Homo sapiens"],"PMID":["[42601936]"]}}