{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328882"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A regulatory TRIF/IL-1R1 axis controls T-dependent IgA production in the intestines","description":"This study investigates the innate signals that constrain intestinal IgA induction. Using single-cell RNA sequencing (scRNA-seq), we profiled the Peyer's patch immune landscape in wild-type, Trif-/-, and Il1r1-/- mice. Our analysis reveals that TRIF and IL-1R1 act as molecular \"brakes\" on mucosal humoral immunity. The dataset provides a high-resolution map of how TRIF and IL-1R1 modulate the B cell microenvironment and intrinsic differentiation pathways to limit mucosal IgA responses.","dates":{"publication":"2026/06/01"},"accession":"GSE328882","cross_references":{"GSM":["GSM9693389","GSM9693387","GSM9693388","GSM9693390"],"GPL":["34290"],"GSE":["328882"],"taxon":["Mus musculus"]}}