{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328885/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328885"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice","description":"Liver regeneration following partial hepatectomy (PHx) requires coordinated metabolic and inflammatory responses. Here, we investigated the contribution of intestinal SIRT1 to hepatic transcriptional reprogramming during early regeneration. Intestinal-specific SIRT1 knockout mice (SIRTintKO) and wild-type (WT) littermates were subjected to PHx, and liver tissue was collected at 6 h and 24 h post-surgery. Bulk RNA sequencing was performed to characterize genotype- and time-dependent transcriptional changes. This dataset provides insight into gut–liver axis regulation of early regenerative priming and metabolic adaptation.","dates":{"publication":"2026/04/28"},"accession":"GSE328885","cross_references":{"GSM":["GSM9693408","GSM9693409","GSM9693404","GSM9693426","GSM9693427","GSM9693405","GSM9693428","GSM9693406","GSM9693429","GSM9693407","GSM9693411","GSM9693412","GSM9693413","GSM9693414","GSM9693430","GSM9693431","GSM9693432","GSM9693410","GSM9693399","GSM9693419","GSM9693415","GSM9693416","GSM9693417","GSM9693418","GSM9693422","GSM9693400","GSM9693401","GSM9693423","GSM9693424","GSM9693402","GSM9693425","GSM9693403","GSM9693420","GSM9693421"],"GPL":["34328"],"GSE":["328885"],"taxon":["Mus musculus"]}}