{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328924/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328924"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic landscape of ketone body–mediated modulation of renal mTORC1 signaling in proximal tubule–specific Tsc1 knockout mice","description":"We performed single-cell RNA sequencing of mouse kidneys to investigate the effects of ketone bodies on renal mTORC1 signaling. A proximal tubule–specific Tsc1 knockout model (PTC- iKO) was used to induce constitutive mTORC1 activation. 1,3-butanediol, a precursor of ketone bodies that elevates circulating ketone levels, was administered as a dietary supplement. Three groups were analyzed: Tsc1 flox controls, Tsc1 PTC-iKO under a normal diet, and Tsc1 PTC-iKO with 1,3-butanediol treatment. This dataset enables cell type–specific analysis of transcriptional changes associated with mTORC1 activation and ketone body exposure in the kidney.","dates":{"publication":"2026/08/25"},"accession":"GSE328924","cross_references":{"GSM":["GSM9694316","GSM9694318","GSM9694317"],"GPL":["24247"],"GSE":["328924"],"taxon":["Mus musculus"]}}