{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329123/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329123"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic and single-cell ATAC analysis of virtual memory T cells In vitro induced from WT and Cd4-Cre Rpa1fl/fl CD8+ T cells","description":"Virtual memory CD8+ T (TVM) cells are a distinct subset of antigen-inexperienced cells with rapid effector potential, but their regulatory checkpoints remain elusive. Here, using single-cell RNA sequencing and single-cell ATAC sequencing, we found that loss of RPA1 promotes chromatin remodeling in CD8+ T cells, leading to enhanced accessibility at EOMES-associated loci and activation of transcriptional programs that drive TVM cell polarization.","dates":{"publication":"2026/04/30"},"accession":"GSE329123","cross_references":{"GSM":["GSM9697930","GSM9697929","GSM9697927","GSM9697928"],"GPL":["24247"],"GSE":["329123"],"taxon":["Mus musculus"]}}