GEOGenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329123GEOGSEfalseSingle-cell transcriptomic and single-cell ATAC analysis of virtual memory T cells In vitro induced from WT and Cd4-Cre Rpa1fl/fl CD8+ T cellsVirtual memory CD8+ T (TVM) cells are a distinct subset of antigen-inexperienced cells with rapid effector potential, but their regulatory checkpoints remain elusive. Here, using single-cell RNA sequencing and single-cell ATAC sequencing, we found that loss of RPA1 promotes chromatin remodeling in CD8+ T cells, leading to enhanced accessibility at EOMES-associated loci and activation of transcriptional programs that drive TVM cell polarization.2026/04/30GSE329123GSM9697930GSM9697929GSM9697927GSM969792824247329123Mus musculus