{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329190/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329190"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Zanubrutinib monotherapy for IgG4-related head and neck disease","description":"IgG4-related disease (IgG4-RD) is commonly treated withglucocorticoids and B cell depletion, but cumulative toxicity and relapse underscore the need for alternative approaches. In this phase 2 open-label proof-of-concept trial, ten participants with lacrimal and submandibular gland IgG4-RD received zanubrutinib 80 mg twice daily without glucocorticoid induction or background immunosuppression. The primary endpoint was change in lacrimal and submandibular gland volume at week 24, assessed by blinded FDG–PET/MRI (evaluable n=8). Mean percent change from baseline was −46.7% for lacrimal and −29.9% for submandibular gland volume (both P=0.008), with concordant reductions in total lesion glycolysis (−91.6 g) and serum IgG4 (−417.0 mg/dL). We also Single-cell immune profiling demonstrated reversal of disease-associated B cell transcriptional programs, selective suppression of IgG4-skewed plasmablasts, and attenuation of cytotoxic CD4⁺ T cells. Adverse events were mild; one serious event occurred (COVID-19). These findings support BTK inhibition as a steroid-sparing, non-B-cell-depleting therapeutic strategy in IgG4-RD. ClinicalTrials.gov identifier: NCT04602598.","dates":{"publication":"2026/07/16"},"accession":"GSE329190","cross_references":{"GSM":["GSM9699030","GSM9699039","GSM9699038","GSM9699037","GSM9699036","GSM9699035","GSM9699034","GSM9699033","GSM9699032","GSM9699031","GSM9699063","GSM9699062","GSM9699061","GSM9699060","GSM9699029","GSM9699028","GSM9699027","GSM9699026","GSM9699025","GSM9699024","GSM9699068","GSM9699067","GSM9699023","GSM9699022","GSM9699066","GSM9699021","GSM9699065","GSM9699064","GSM9699020","GSM9699052","GSM9699051","GSM9699050","GSM9699019","GSM9699018","GSM9699017","GSM9699016","GSM9699015","GSM9699059","GSM9699058","GSM9699014","GSM9699013","GSM9699057","GSM9699056","GSM9699012","GSM9699011","GSM9699055","GSM9699010","GSM9699054","GSM9699053","GSM9699041","GSM9699040","GSM9699009","GSM9699008","GSM9699007","GSM9699049","GSM9699048","GSM9699047","GSM9699046","GSM9699045","GSM9699044","GSM9699043","GSM9699042"],"GPL":["34284"],"GSE":["329190"],"taxon":["Homo sapiens"]}}