{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329199/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329199"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Age-dependent CNS responses to Powassan virus infection revealed by single-cell RNA sequencing","description":"Powassan virus (POWV) causes highly lethal encephalitis in the elderly and long-term cognitive deficits in survivors. Mirroring human severity, POWV LI9 directs age-dependent lethality in B6 mice resulting in spongiform encephalitis, gliosis and inflammatory cytokine/chemokine responses in the CNS. Here we analyzed POWV LI9 infected brains from 10 (young) and 50 week old (aged) B6 mice using 10x Genomics scRNA-seq to define CNS responses that direct age-dependent lethality.","dates":{"publication":"2026/05/28"},"accession":"GSE329199","cross_references":{"GSM":["GSM9699184","GSM9699183","GSM9699182","GSM9699181","GSM9699180","GSM9699179"],"GPL":["34290"],"GSE":["329199"],"taxon":["Mus musculus"]}}