GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329199/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329199GEOGSEfalseAge-dependent CNS responses to Powassan virus infection revealed by single-cell RNA sequencingPowassan virus (POWV) causes highly lethal encephalitis in the elderly and long-term cognitive deficits in survivors. Mirroring human severity, POWV LI9 directs age-dependent lethality in B6 mice resulting in spongiform encephalitis, gliosis and inflammatory cytokine/chemokine responses in the CNS. Here we analyzed POWV LI9 infected brains from 10 (young) and 50 week old (aged) B6 mice using 10x Genomics scRNA-seq to define CNS responses that direct age-dependent lethality.2026/05/28GSE329199GSM9699184GSM9699183GSM9699182GSM9699181GSM9699180GSM969917934290329199Mus musculus