{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329380/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329380"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A contamination-adjusted tissue thrombopoietic framework identifies a clinically relevant CAF-myeloid niche in non-small cell lung cancer: a paired transcriptomic and survival study","description":"Platelet-related cancer biology is often studied through circulating markers, but tissue-centered thrombopoietic programs in lung cancer are difficult to distinguish from blood-contamination artifacts. In this study, paired bulk RNA-seq profiles were generated from human non-small cell lung cancer tumor tissues and matched adjacent non-tumor lung tissues. Sample identifiers beginning with C denote tumor tissue libraries, and identifiers beginning with N denote matched adjacent non-tumor tissue libraries; shared numeric suffixes indicate patient pairing. These data were used as the local discovery layer for a contamination-adjusted megakaryopoiesis-platelet tumor axis (MPTA) framework. The analysis combined paired differential expression, explicit contamination-aware score construction, public single-cell and spatial reference analyses, external cohort assessment, and local clinicopathologic and survival evaluation. The deposited sequencing data support the tumor-adjacent transcriptomic comparisons and locked tissue-centered MPTA score construction described in the manuscript.","dates":{"publication":"2026/06/03"},"accession":"GSE329380","cross_references":{"GSM":["GSM9702850","GSM9702851","GSM9702854","GSM9702855","GSM9702852","GSM9702853","GSM9702858","GSM9702859","GSM9702856","GSM9702857","GSM9702840","GSM9702843","GSM9702844","GSM9702841","GSM9702842","GSM9702847","GSM9702848","GSM9702845","GSM9702846","GSM9702849","GSM9702872","GSM9702873","GSM9702870","GSM9702871","GSM9702755","GSM9702876","GSM9702877","GSM9702756","GSM9702874","GSM9702753","GSM9702754","GSM9702875","GSM9702759","GSM9702757","GSM9702878","GSM9702758","GSM9702879","GSM9702861","GSM9702862","GSM9702860","GSM9702865","GSM9702866","GSM9702863","GSM9702864","GSM9702869","GSM9702867","GSM9702868","GSM9702809","GSM9702770","GSM9702773","GSM9702774","GSM9702771","GSM9702772","GSM9702777","GSM9702810","GSM9702811","GSM9702778","GSM9702775","GSM9702776","GSM9702814","GSM9702815","GSM9702812","GSM9702779","GSM9702813","GSM9702818","GSM9702819","GSM9702816","GSM9702817","GSM9702880","GSM9702762","GSM9702883","GSM9702763","GSM9702884","GSM9702760","GSM9702881","GSM9702761","GSM9702882","GSM9702766","GSM9702887","GSM9702888","GSM9702800","GSM9702767","GSM9702764","GSM9702885","GSM9702765","GSM9702886","GSM9702803","GSM9702804","GSM9702768","GSM9702889","GSM9702801","GSM9702769","GSM9702802","GSM9702807","GSM9702808","GSM9702805","GSM9702806","GSM9702791","GSM9702792","GSM9702790","GSM9702795","GSM9702796","GSM9702793","GSM9702794","GSM9702832","GSM9702799","GSM9702833","GSM9702797","GSM9702830","GSM9702831","GSM9702798","GSM9702836","GSM9702837","GSM9702834","GSM9702835","GSM9702838","GSM9702839","GSM9702780","GSM9702781","GSM9702784","GSM9702785","GSM9702782","GSM9702783","GSM9702788","GSM9702821","GSM9702789","GSM9702822","GSM9702786","GSM9702820","GSM9702787","GSM9702825","GSM9702826","GSM9702823","GSM9702824","GSM9702829","GSM9702827","GSM9702828"],"GPL":["21290"],"GSE":["329380"],"taxon":["Homo sapiens"],"PMID":["[42057042]"]}}