GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329380/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329380GEOGSEfalseA contamination-adjusted tissue thrombopoietic framework identifies a clinically relevant CAF-myeloid niche in non-small cell lung cancer: a paired transcriptomic and survival studyPlatelet-related cancer biology is often studied through circulating markers, but tissue-centered thrombopoietic programs in lung cancer are difficult to distinguish from blood-contamination artifacts. In this study, paired bulk RNA-seq profiles were generated from human non-small cell lung cancer tumor tissues and matched adjacent non-tumor lung tissues. Sample identifiers beginning with C denote tumor tissue libraries, and identifiers beginning with N denote matched adjacent non-tumor tissue libraries; shared numeric suffixes indicate patient pairing. These data were used as the local discovery layer for a contamination-adjusted megakaryopoiesis-platelet tumor axis (MPTA) framework. The analysis combined paired differential expression, explicit contamination-aware score construction, public single-cell and spatial reference analyses, external cohort assessment, and local clinicopathologic and survival evaluation. The deposited sequencing data support the tumor-adjacent transcriptomic comparisons and locked tissue-centered MPTA score construction described in the manuscript.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 sapiens[42057042]