{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329469/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329469"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Human iPSC-Derived Cardiac Progenitor Cells Recapitulate Endogenous CPC Function and Offer a Rejuvenated Cell Source for Cardiac Regeneration","description":"Cardiac progenitor cells (CPCs) derived from human induced pluripotent stem cells (hiPSCs) represent a promising alternative to CPC isolation from adult hearts avoiding the need for invasive myocardial biopsy and potentially overcoming the age-related decline in CPC function. Human iPSC-derived CPCs have previously been generated however current strategies are limited by the generation of developmentally immature and heterogeneous progenitor populations with restricted expansion capacity. A lack of donor-matched comparisons with native human CPCs has also limited insight into their developmental fidelity, functional competence, and translational relevance. Together, this study provides the first comprehensive donor-matched comparison of hiPSC-derived and native CPCs, establishing hiPSC-CPCs as an accessible, standardised, and rejuvenated progenitor source that closely mirrors native CPC identity and function. These findings support the potential application of hiPSC-CPCs for cardiac regenerative medicine applications.","dates":{"publication":"2026/05/04"},"accession":"GSE329469","cross_references":{"GSM":["GSM9704790","GSM9704794","GSM9704793","GSM9704792","GSM9704791","GSM9704798","GSM9704787","GSM9704797","GSM9704786","GSM9704796","GSM9704795","GSM9704789","GSM9704788"],"GPL":["24676"],"GSE":["329469"],"taxon":["Homo sapiens"]}}