GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329469/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329469GEOGSEfalseHuman iPSC-Derived Cardiac Progenitor Cells Recapitulate Endogenous CPC Function and Offer a Rejuvenated Cell Source for Cardiac RegenerationCardiac progenitor cells (CPCs) derived from human induced pluripotent stem cells (hiPSCs) represent a promising alternative to CPC isolation from adult hearts avoiding the need for invasive myocardial biopsy and potentially overcoming the age-related decline in CPC function. Human iPSC-derived CPCs have previously been generated however current strategies are limited by the generation of developmentally immature and heterogeneous progenitor populations with restricted expansion capacity. A lack of donor-matched comparisons with native human CPCs has also limited insight into their developmental fidelity, functional competence, and translational relevance. Together, this study provides the first comprehensive donor-matched comparison of hiPSC-derived and native CPCs, establishing hiPSC-CPCs as an accessible, standardised, and rejuvenated progenitor source that closely mirrors native CPC identity and function. These findings support the potential application of hiPSC-CPCs for cardiac regenerative medicine applications.2026/05/04GSE329469GSM9704790GSM9704794GSM9704793GSM9704792GSM9704791GSM9704798GSM9704787GSM9704797GSM9704786GSM9704796GSM9704795GSM9704789GSM970478824676329469Homo sapiens