{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329539/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329539"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hypothalamic transcriptomic response to High-Fat Diet induced obesity: modulatory effects of Resveratrol, Curcumin, and Aged Garlic Extract.","description":"Obesity is a multifaceted disorder driven by the dysregulation of homeostatic mechanisms in the hypothalamus, often resulting from dietary-induced lipotoxicity and chronic neuroinflammation. This research investigates the transcriptomic shifts in the hypothalamus during the progression of High-Fat Diet (HFD) induced obesity in juvenile male C57BL/6 mice. Mice were subjected to an 8-week HFD protocol (60% kcal from fat) starting at 8 weeks of age to establish a robust obese phenotype. We explored the therapeutic efficacy of three bioactive compounds known for their antioxidant and anti-inflammatory activities: Resveratrol (2.25 mg/kg), Curcumin (50 mg/kg), and Aged Garlic Extract (200 mg/kg), administered daily during the last four weeks of the study. Through high-throughput RNA sequencing (RNA-seq), we aim to elucidate how these compounds mitigate HFD-induced transcriptomic perturbations. This study offers critical insights into the molecular basis of obesity-related neuroinflammation and identifies specific gene clusters that can be targeted by bioactive-rich dietary strategies to counteract hypothalamic dysfunction. https://doi.org/10.3390/genes17030297","dates":{"publication":"2026/04/29"},"accession":"GSE329539","cross_references":{"GSM":["GSM9706027","GSM9706028","GSM9706029","GSM9706034","GSM9706023","GSM9706024","GSM9706025","GSM9706026","GSM9706030","GSM9706031","GSM9706032","GSM9706033"],"GPL":["24247"],"GSE":["329539"],"taxon":["Mus musculus"],"PMID":["[41898832]"],"DOI":["10.3390/genes17030297"]}}