{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329568/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329568"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic of Visceral Adipose Tissue in HFD-induced obesity: evaluation of Resveratrol","description":"Visceral adipose tissue (VAT) expansion during the development of obesity is a hallmark of metabolic syndrome, characterized by hypoxia, oxidative stress, and a shift toward a pro-inflammatory secretome. This series examines the transcriptomic profile of VAT in male C57BL/6 mice subjected to long-term obesity induced by a high-fat diet (HFD, 60% of kcal from fat). To investigate new therapeutic avenues, we evaluated the impact of daily resveratrol administration (2.25 mg/kg) for 28 days, beginning at week 16 of life (8 weeks on the HFD diet). Using a transcriptomic approach (RNA-seq), we mapped the expression changes associated with the transition from healthy to dysfunctional adipose tissue. This study provides a detailed molecular resource for understanding how obesity-induced adipocyte stress can be attenuated by natural bioactives.","dates":{"publication":"2026/05/04"},"accession":"GSE329568","cross_references":{"GSM":["GSM9706496","GSM9706497","GSM9706493","GSM9706494","GSM9706495"],"GPL":["24247"],"GSE":["329568"],"taxon":["Mus musculus"]}}