{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329902/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329902"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Beta-hydroxybutyrate enhances mitochondrial energy metabolism through histone beta-hydroxybutyrylation","description":"Beta-hydroxybutyrate (BHB) regulates gene expression through modulation of post-translational histone modifications, including histone beta-hydroxybutyrylation. In human renal tubular epithelial cells challenged with hydrogen peroxide, pretreatment with sodium beta-hydroxybutyrate (BHBNa) significantly upregulated global histone beta-hydroxybutyrylation marks, specifically enhancing beta-hydroxybutyrylation at histone H3 lysine 4 (H3K4bhb) compared to hydrogen peroxide treatment alone. To investigate whether BHB enhances mitochondrial energy metabolism via this epigenetic mechanism, we performed chromatin immunoprecipitation sequencing (ChIP-seq) specifically targeting H3K4bhb.","dates":{"publication":"2026/05/09"},"accession":"GSE329902","cross_references":{"GSM":["GSM9712914","GSM9712915","GSM9712916","GSM9712917"],"GPL":["24676"],"GSE":["329902"],"taxon":["Homo sapiens"]}}