GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329902/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329902GEOGSEfalseBeta-hydroxybutyrate enhances mitochondrial energy metabolism through histone beta-hydroxybutyrylationBeta-hydroxybutyrate (BHB) regulates gene expression through modulation of post-translational histone modifications, including histone beta-hydroxybutyrylation. In human renal tubular epithelial cells challenged with hydrogen peroxide, pretreatment with sodium beta-hydroxybutyrate (BHBNa) significantly upregulated global histone beta-hydroxybutyrylation marks, specifically enhancing beta-hydroxybutyrylation at histone H3 lysine 4 (H3K4bhb) compared to hydrogen peroxide treatment alone. To investigate whether BHB enhances mitochondrial energy metabolism via this epigenetic mechanism, we performed chromatin immunoprecipitation sequencing (ChIP-seq) specifically targeting H3K4bhb.2026/05/09GSE329902GSM9712914GSM9712915GSM9712916GSM971291724676329902Homo sapiens