GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329905/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329905GEOGSEfalsesnRNA-seq profiling of the ascending aorta and aortic arch from male and female Wnt1-Cre;Rosa26-mTmG miceVascular smooth muscle cells (VSMCs) in the ascending aorta and aortic arch arise from two distinct embryonic origins: the second heart field (SHF) and the cardiac neural crest (CNC). Whether these populations exhibit sex-dependent differences remains unknown. In this study, we generated Wnt1-Cre/Rosa26-mTmG lineage-tracing mice and performed single-nucleus RNA sequencing using the ascending aortae and aortic arch from both sexes. This study revealed the differential expression of VSMCs from different embryonic origin in both sexes.2026/05/15GSE329905GSM9712942GSM971294324247329905Mus musculus