GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329964/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329964GEOGSEfalseNasopharyngeal Swab Transcriptomics Reveals Distinct Pathogenic Mechanisms in Adenoid Hypertrophy and Allergic RhinitisAdenoid hypertrophy (AH) frequently coexists with allergic rhinitis (AR) in children, yet the molecular mechanisms underlying this comorbidity remain unclear. Using nasopharyngeal swab-based transcriptomics—enabling inclusion of healthy pediatric controls previously precluded by ethical constraints—this study aimed to characterize the transcriptomic landscape of AH with and without AR and identify disease-specific pathogenic pathways. We performed RNA sequencing on nasopharyngeal swab samples from 25 pediatric subjects, including healthy controls (HC, n=6), children with AH (n=10), and children with AH accompanied by AR (AHAR, n=9). This study underscores the need for individualized therapeutic strategies tailored to distinct disease mechanisms in pediatric upper airway disorders.2026/08/19GSE329964GSM9714135GSM9714134GSM9714137GSM9714136GSM9714139GSM9714138GSM9714131GSM9714130GSM9714133GSM9714132GSM9714124GSM9714123GSM9714126GSM9714125GSM9714128GSM9714127GSM9714129GSM9714140GSM9714142GSM9714120GSM9714141GSM9714144GSM9714122GSM9714121GSM971414324676329964Homo sapiens[42591655]