{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330326/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330326"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NAB2::STAT6 Fusion Proteins Drive Nuclear Condensate Formation and Transcriptional Reprogramming in Solitary Fibrous Tumors","description":"Solitary fibrous tumor (SFT) is a rare and aggressive sarcoma driven by NAB2::STAT6 gene fusions, yet effective targeted therapies remain unavailable. Here, we report that the NAB2ex4::STAT6ex2 fusion variant forms nuclear condensates via liquid-liquid phase separation (LLPS) in engineered fibroblast models and primary SFT cells. These condensates co-localize with BRD4S and EGR1, key transcriptional regulators, and are functionally active, driving widespread transcriptional reprogramming. Treatment with Mithramycin A, a compound that disrupts EGR1-DNA interactions, dissolves NAB2::STAT6 condensates and reverses their aberrant gene expression and chromatin binding signatures. Our findings uncover a previously unrecognized role for NAB2::STAT6 in condensate-mediated oncogenic signaling and provide a mechanistic rationale for condensate-targeted therapy in SFT.","dates":{"publication":"2026/06/05"},"accession":"GSE330326","cross_references":{"GSM":["GSM9723849","GSM9723848","GSM9723869","GSM9723847","GSM9723846","GSM9723868","GSM9723867","GSM9723866","GSM9723865","GSM9723864","GSM9723863","GSM9723862","GSM9723861","GSM9723860","GSM9723881","GSM9723880","GSM9723859","GSM9723858","GSM9723857","GSM9723879","GSM9723878","GSM9723856","GSM9723877","GSM9723855","GSM9723854","GSM9723876","GSM9723875","GSM9723853","GSM9723874","GSM9723852","GSM9723851","GSM9723873","GSM9723872","GSM9723850","GSM9723871","GSM9723870"],"GPL":["34284"],"GSE":["330326"],"taxon":["Homo sapiens"],"PMID":["[42176797]"]}}