GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330326/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330326GEOGSEfalseNAB2::STAT6 Fusion Proteins Drive Nuclear Condensate Formation and Transcriptional Reprogramming in Solitary Fibrous TumorsSolitary fibrous tumor (SFT) is a rare and aggressive sarcoma driven by NAB2::STAT6 gene fusions, yet effective targeted therapies remain unavailable. Here, we report that the NAB2ex4::STAT6ex2 fusion variant forms nuclear condensates via liquid-liquid phase separation (LLPS) in engineered fibroblast models and primary SFT cells. These condensates co-localize with BRD4S and EGR1, key transcriptional regulators, and are functionally active, driving widespread transcriptional reprogramming. Treatment with Mithramycin A, a compound that disrupts EGR1-DNA interactions, dissolves NAB2::STAT6 condensates and reverses their aberrant gene expression and chromatin binding signatures. Our findings uncover a previously unrecognized role for NAB2::STAT6 in condensate-mediated oncogenic signaling and provide a mechanistic rationale for condensate-targeted therapy in SFT.2026/06/05GSE330326GSM9723849GSM9723848GSM9723869GSM9723847GSM9723846GSM9723868GSM9723867GSM9723866GSM9723865GSM9723864GSM9723863GSM9723862GSM9723861GSM9723860GSM9723881GSM9723880GSM9723859GSM9723858GSM9723857GSM9723879GSM9723878GSM9723856GSM9723877GSM9723855GSM9723854GSM9723876GSM9723875GSM9723853GSM9723874GSM9723852GSM9723851GSM9723873GSM9723872GSM9723850GSM9723871GSM972387034284330326Homo sapiens[42176797]