{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Pyricularia oryzae"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330356"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The secreted protein MoSun4 of Magnaporthe oryzae regulates pathogenicity by repressing the expression of virulence-related genes","description":"The SUN family protein MoSun4 in Magnaporthe oryzae has been previously implicated in mitophagy and can be used as a target for reducing rice blast, but its role as a secreted protein remain poorly understood. In this study, signal peptide prediction and yeast secretion assays confirmed the activity of MoSun4 signal peptide, and co-localization revealed its extra-invasive hyphal membrane (EIHM) localization, establishing MoSun4 as a secreted protein. In addition, deletion of MoSUN4 severely attenuated the hyphal growth, conidiation and virulence of M. oryzae. We further showed that MoSun4 represses the expression of virulence-related genes, including multiple genes involved in cell wall degradation (eglC, eglD), secondary metabolism (gliK), and melanin biosynthesis (SDH1, BUF1, Cmr1, ALB1). Collectively, our study reveals that MoSun4 is a secreted protein and regulates pathogenicity by repressing the expression of virulence-related genes, providing new insights into the function of SUN family proteins.","dates":{"publication":"2026/05/20"},"accession":"GSE330356","cross_references":{"GSM":["GSM9724341","GSM9724340","GSM9724339","GSM9724344","GSM9724343","GSM9724342"],"GPL":["36936"],"GSE":["330356"],"taxon":["Pyricularia oryzae"]}}