{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330450/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Macaca fascicularis"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330450"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The single-nucleus RNA-seq of AAV-Abeta42 injected hippocampus of crab-eating macaque","description":"In our previous work, we found that hippocampal injection of AAV-Aβ42 induced robust Aβ deposition, increased abnormal phosphorylated tau (pTau) pathology, and neurodegeneration in the aged hippocampus, but not in young monkeys. To investigate the mechanisms underlying this age-dependent difference, we performed single-nucleus RNA sequencing (snRNA-seq) on monkeys at two developmental stages.","dates":{"publication":"2026/05/11"},"accession":"GSE330450","cross_references":{"GSM":["GSM9726487","GSM9726476","GSM9726477","GSM9726478","GSM9726479","GSM9726480","GSM9726481","GSM9726482","GSM9726483","GSM9726484","GSM9726485","GSM9726486"],"GPL":["24953"],"GSE":["330450"],"taxon":["Macaca fascicularis"]}}