{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330469/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330469"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [CUT&Tag]","description":"This study generated ChIP-seq and CUT&Tag datasets to profile genome-wide occupancy of YAP, TAZ, TEAD1, SMAD3, and VGLL4 in the human hepatocellular carcinoma cell line HCCLM3. Profiling was performed under four conditions: untreated control, TGF-beta1 stimulation (2.5 ng/ml for 2 h), siRNA-mediated knockdown of YAP and TAZ followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h), and stable KLF2 overexpression followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h). ChIP-seq was also used to profile the histone modifications H3K27ac, H3K4me1, H3K4me3, and H3K18la. These datasets provide a resource for studying transcription factor binding and chromatin states in HCCLM3 cells.","dates":{"publication":"2026/05/16"},"accession":"GSE330469","cross_references":{"GSM":["GSM9727280","GSM9727281","GSM9727270","GSM9727282","GSM9727271","GSM9727260","GSM9727261","GSM9727283","GSM9727272","GSM9727273","GSM9727262","GSM9727274","GSM9727263","GSM9727264","GSM9727275","GSM9727276","GSM9727265","GSM9727277","GSM9727266","GSM9727278","GSM9727267","GSM9727279","GSM9727268","GSM9727269"],"GPL":["24676"],"GSE":["330469"],"taxon":["Homo sapiens"]}}