{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330470/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330470"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [ChIP-seq]","description":"This study generated ChIP-seq and CUT&Tag datasets to profile genome-wide occupancy of YAP, TAZ, TEAD1, SMAD3, and VGLL4 in the human hepatocellular carcinoma cell line HCCLM3. Profiling was performed under four conditions: untreated control, TGF-beta1 stimulation (2.5 ng/ml for 2 h), siRNA-mediated knockdown of YAP and TAZ followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h), and stable KLF2 overexpression followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h). ChIP-seq was also used to profile the histone modifications H3K27ac, H3K4me1, H3K4me3, and H3K18la. These datasets provide a resource for studying transcription factor binding and chromatin states in HCCLM3 cells.","dates":{"publication":"2026/05/16"},"accession":"GSE330470","cross_references":{"GSM":["GSM9727310","GSM9727311","GSM9727312","GSM9727313","GSM9727314","GSM9727315","GSM9727316","GSM9727317","GSM9727318","GSM9727319","GSM9727284","GSM9727285","GSM9727286","GSM9727320","GSM9727287","GSM9727288","GSM9727321","GSM9727289","GSM9727322","GSM9727323","GSM9727324","GSM9727325","GSM9727326","GSM9727327","GSM9727328","GSM9727329","GSM9727290","GSM9727291","GSM9727292","GSM9727293","GSM9727294","GSM9727295","GSM9727296","GSM9727297","GSM9727330","GSM9727331","GSM9727298","GSM9727332","GSM9727299","GSM9727333","GSM9727334","GSM9727335","GSM9727336","GSM9727337","GSM9727338","GSM9727300","GSM9727301","GSM9727302","GSM9727303","GSM9727304","GSM9727305","GSM9727306","GSM9727307","GSM9727308","GSM9727309"],"GPL":["24676"],"GSE":["330470"],"taxon":["Homo sapiens"]}}